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Professor, Departments of Psychiatry and Anatomy and Neurobiology B.S.
in Psychology (1964) M.S.
in Experimental Psychology (1966) Ph.D.
in Neuropharmacology (1969) Postdoctoral
Training (1968-1970) |
Our research program focuses on the role of endogenous opioid peptides (EOP) in the control of hypothalamic-pituitary function. We are especially interested in the mechanisms by which EOP influence the release of hypothalamic releasing factors, particularly luteinizing hormone releasing hormone (LHRH), and the role these peptides play in the regulation of spermatogenesis and steroidogenesis in the testes. In addition to our strong interest in the interaction between EOP and the endocrine system, we are also examining the influence of abused substances on neuroendocrine function. Our interests fall into two general areas. First, the effects of substances of abuse administered during the prepubescent period on the onset of puberty and sexual maturation. As an integral part of these studies we are also exploring the hypothesis that the maturation of the EOP system represents the "trigger" for the onset of puberty, which has thus far eluded identification. Second, we have observed that the treatment of male rats with several abused compounds, such as morphine and alcohol, for a brief period of time followed by a drug free period, has adverse effects on their male and female offspring, particularly with respect to their neuroendocrine development and cognitive abilities. The mechanisms underlying these potentially important trans-generational effects of substances of abuse are actively under investigation. Our studies involve many levels of analysis: whole animal pharmacology, tissue culture, in vitro superfusion of various organs, biochemical analyses and a variety of other techniques in molecular biology.
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Inciardi JA, Cicero TJ, Munoz A, Adams EH, Geller A, Senay EC, and Woody GE (2006) The diversion of Ultram, Ultracet, and generic tramadol HCL. J Addict Dis. 25(2): 53-8. |
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Adams EH, Breiner S, Cicero TJ, Geller A, Inciardi JA, Schnoll SH, Senay EC, and Woody GE (2006) A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain. J Pain Symptom Manage. 31(5): 465-76. |
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Cicero TJ, Inciardi JA (2005) Potential for abuse of buprenorphine in office-based treatment of opioid dependence. New England Journal of Medicine. 353(17): 1863-5. |
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Cicero TJ, Inciardi JA and Munoz A (2005) Trends in abuse of Oxycontin and other opioid analgesics in the United States. J Pain 6(10): 662-72. |
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Peckham EM, Barkley LM, Divin MF, Cicero TJ and Traynor JR (2005) Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox. Brain Research. 1058(1-2): 137-47. |
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Cicero TJ, Inciardi JA, Adams EH, Geller A, Senay EC, Woody GE, and Munoz A (2005) Rates of abuse of tramadol remain unchanged with the introduction of new branded and generic products: results of an abuse monitoring system, 1994-2004. Pharmacoepidemiol Drug Saf. May 12 epub ahead of print. |
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Cicero TJ, and Inciardi JA (2005) Diversion and abuse of methadone prescribed for pain management. JAMA 293(3): 297-8. |
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Nock B, Cicero TJ, and Wich M (2005) Chronic morphine increases the pituitary-adrenocortical response of juvenile rats to mild stress. Pharmacol Biochem Behav. 80(1): 77-85. |
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Woody GE, Senay EC, Geller A, Adams EH, Inciardi JA, Schnoll S, Munoz A and Cicero TJ (2003) An independent assessment of MEDWatch reporting for abuse/dependence and withdrawal from Ultram (tramadol hydrochloride). Drug Alcohol Depend. 72(2): 163-8. |
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Arfken CL and Cicero TJ (2003) Postmarketing surveillance for drug abuse. Drug Alcohol Depend. 70(3 Suppl): S97-105. Review. |
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Senay EC, Adams EH, Geller A, Inciardi JA, Munoz A, Schnoll SH, Woody GE and Cicero TJ (2003) Physical dependence on Ultram (tramadol hydrochloride): both opioid-like and atypical withdrawal symptoms occur. Drug Alcohol Depend. 69(3): 233-41. |
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Cicero TJ, Aylward SC and Meyer ER (2003) Gender differences in the intravenous self-administration of mu opiate agonists. Pharmacol Biochem Behav. 74(3): 541-49. |
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Cicero TJ, Nock B and Meyer ER (2002) Gender-linked differences in the expression of physical dependence in the rat. Pharmacol Biochem Behav. 72(3): 691-97. |
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Cicero TJ, Davis LA, LaRegina MC, Meyer ER and Schlegel MS (2002) Chronic opiate exposure in the male rat adversely affects fertility. Pharmacol Biochem Behav. 72(1-2): 157-63. |
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Cicero TJ, Nock B, O'Connor L and Meyer ER (2002) Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects. J Pharmacol Exp Ther 300(2): 695-701. |
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Nock B, Wich M, Cicero TJ and O'Connor LH (2000) Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested. Pharmacol Biochem Behav. 67(1): 193-8. |
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Cicero TJ, Ennis T, Ogden J and Meyer ER (2000) Gender differences in the reinforcing properties of morphine. Pharmacol Biochem Behav. 65(1): 91-6. |
