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The Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology and Professor of Medicine B.A.
in Chemistry and History (1971) Medical
Degree (1975) Residencies
in Medicine and Neurology Postdoctoral
Fellow in Neurology |
Dr. Clifford has a broad interest in neuropharmacology. Development of more successful medical management of neurological disease has been his clinical focus, and has included participation in studies of epilepsy, Parkinson's disease, multiple sclerosis, and virtually all neurologic complications of HIV. His present focus is on developing optimal treatments for neurologic complications of HIV including HIV-associated dementia, painful peripheral neuropathies in HIV, progressive multifocal leukoencephalopathy, cryptococcal meningitis, toxoplasma encephalitis, primary CNS lymphoma, cytomegalovirus encephalitis/radiculomyelitis, and HIV myelopathy. Dr. Clifford leads a nationwide clinical research group, the Neurologic AIDS Research Consortium, funded by NINDS of the National Institute of Health, whose specific mission is to pursue better treatments for HIV associated neurologic complications. He is also Principal Investigator for the Washington University AIDS Clinical Trials Unit. He is working in international studies, particularly cooperating with medical schools of Ethiopia to further diagnosis and treatment of HIV in that country. |
Tyler K, York GK, Steinberg DA, Okun MS, Steinbach M, Satran R, Fine EJ, Manteghi T, Bleck TP, Swanson JW, Mishra S. Meador KJ, Clifford DB, Toole JF, and Melson L (2003) Part 2: history of 20th century neurology: decade by decade. Ann Neurol. 53 Suppl 4: S27-45. |
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Cinque P, Koralnik IJ, and Clifford DB (2003) The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: defining and consensus terminology. Journal of Neurovirology 9 Suppl 1: 88-92. |
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Clifford DB (2003) Challenges for clinical trials to treat progressive multifocal leukoenephalopathy. Journal of Neurovirology 9 Suppl 1: 68-72. |
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Avasarala JR, Coress AH, Clifford DB, Singer BA, Siegel BA, and Abbey EE (2003) Rapid onset mitoxantrone-induced cardiotoxicity in secondary progressive multiple sclerosis. Multiple Sclerosis 9(1): 59-62. |
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Izumi Y, Benz AM, Katsuki H, Matsukawa M, Clifford DB, and Zorumski CF (2003) Effects of fructose-1, 6-bisphosphate on morphological and functional neuronal integrity in rat hippocampal slices during energy deprivation. Neuroscience 116(2): 465-75. |
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Clifford DB, McArthur JC, Schifitto G, Kieburtz K, McDermott MP, Letendre S, Cohen BA, Marder K, Ellis RJ, and Marra CM; Neurologic AIDS Research Consortium (2002) A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology 59(10): 1568-73. |
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Clifford DB (2002) AIDS dementia. Med Clin North Am 86(3): 537-50. |
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Polydefkis M, Yiannoutsos CT, Cohen BA, Hollander H, Schifitto G, Clifford DB, Simpson DM, Katzenstein D, Shriver S, Hauer P, Brown A, Haidich AB, Moo L, and McArthur JC (2002) Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 58(1): 115-19. |
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Schifitto G, Yiannoutsos C, Simpson DM, Adornato BT, Singer EJ, Hollander H, Marra CM, Rubin M, Cohen BA, Tucher T, Koralnik IF, Katzenstein D, Haidich B, Smith ME, Shriver S, Millar L, Clifford DB, McArthur JC; AIDS Clinical Trials Group Team 291 (2001) Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology 57(7): 1313-16. |
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Clifford DB (2001) Challenges for clinical trials on progressive multifocal leukoencephalopathy. Journal of Neurovirology 7(4): 350-52. |
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Reploeg MD, Storch GA and Clifford DB (2001) Bk virus: a clinical review. Clinical Infectious Diseases 33(2): 191-202. |
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