Mark F. Jacquin, Ph.D.

Professor of Neurology

B.A. in Psychology
Brandeis University

Ph.D. in Neurobiology (1980)
City University in New York

The long-term aim of our research is fourfold:

1) to determine the cellular circuitry responsible for the functional
organization of sensory systems;

2) to uncover cellular and molecular principles controlling development of the mammalian peripheral and central nervous systems;

3) to assess the structural and functional consequences of peripheral and central
nervous system injury;

4) to isolate effective strategies for repair of injured neural tissue.

The rodent somatosensory system is being used as a model because of its stereotyped normal organization which lends itself to quantification, its known susceptibility to injury, and its clinical applications.

Yoon YW, Dong H, Arends JJ, and Jacquin MF (2004) Mechanical and cold allodynia in a rat spinal cord contusion model. Somatosensory and Motor Research 21(1): 25-31.

Dong H, Fazzaro A, Xiang C, Dorsmeyer SJ, Jacquin MF, and McDonald JW (2003) Enhance oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. Journal of Neuroscience 23(25): 8682-91.

pdf

Ding, YQ, Yin J, Xu HM, Jacquin MF and Chen ZF (2003) Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. Journal of Neuroscience 23(19): 7246-54.

pdf

Matsuo S, Ichikawa H, Silos-Santiago I, Kiyomiya K, Kurebe M, Arends JJ and Jacquin MF (2002) Ruffini endings are absent from the periodontal ligament of trkB knockout mice. Somatosensory and Motor Research 19(3): 213-17.

pdf

Mosconi T, Snider WD, and Jacquin MF (2001) Neurotrophin receptor expression in retrogradely labeled trigeminal nociceptors - comparisons with spinal nociceptors. Somatosensory and Motor Research 18(4): 312-21.

pdf

Matsuo S, Ichikawa H, Henderson TA, Silos-Santiago I, Barbacid M, Arends JJ, and Jacquin MF (2001) trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice. Neuroscience 105(3): 747-60.

pdf

Ichikawa H, Matsuo S, Silos-Santiago I, Jacquin MF, and Sugimoto T (2001) Developmental dependency of Merkel endings on trks in the palate. Molecular Brain Research 88(1-2): 171-5.

pdf

Veinante P, Jacquin MF, Deschenes M (2000) Thalamic projections from the whisker-sensitive regions of the spinal trigeminal complex in the rat. Journal of Comparative Neurology 420(2): 233-43.

pdf

Ulupinar E, Jacquin MF, and Erzurumlu RS (2000) Differential effects of NGF and NT-3 on embryonic trigeminal axon growth patterns. Journal of Comparative Neurology 425(2): 202-18.

pdf

Matsuo S, Ichikawa H, Silos-Santiago I, Arends JJ, Henderson TA, Kiyomiya K, Kurebe M, and Jacquin MF (2000) Proprioceptive afferents survive in the masseter muscole of trkC knockout mice. Neuroscience 95(1): 209-16.

pdf